VRK1 Polyclonal Antibody

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Active in presence of Mn(2+), Mg(2+) and Zn(2+), but is not functional with Ca(2+) or Cu(2+). Has a higher affinity for Mn(2+) than for Mg(2+).,function:Serine/threonine kinase that phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2.,PTM:Autophosphorylated at various serine and threonine residues. Autophosphorylation does not impair its ability to phosphorylate p53/TP53.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.,tissue specificity:Widely expressed. Highly expressed in fetal liver, testis and thymus.,