function:Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration.,similarity:Contains 1 Ras-GEF domain.,similarity:Contains 1 SH2 domain.,subcellular location:Associated with the membrane when EGF-stimulated. Found at ruffling membranes.,subunit:Interacts with PTK2B. Isoform 2 interacts with BCAR1/CAS and NEDD9/HEF1.,tissue specificity:Ubiquitously expressed.,
Cytoplasm . Cell membrane ; Peripheral membrane protein . Cell projection, axon . Cell projection, ruffle membrane . Associated with the membrane when EGF-stimulated (By similarity). Expressed at the cortical actin ring in B cells (By similarity). .; [Isoform 1]: Cell membrane ; Peripheral membrane protein .
[Isoform 1]: Ubiquitously expressed.
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