CCL13 Polyclonal Antibody

function:Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.,induction:By interleukin-1 and TNF-alpha.,mass spectrometry: PubMed:8642349,miscellaneous:This protein can bind heparin.,online information:CCL13 entry,PTM:One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain.,similarity:Belongs to the intercrine beta (chemokine CC) family.,tissue specificity:Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.,