SCNAA Polyclonal Antibody

domain:The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.,function:This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms.,PTM:Ubiquitinated by NEDD4L; which promotes its endocytosis.,similarity:Belongs to the sodium channel family.,similarity:Contains 1 IQ domain.,subcellular location:It can be translocated to the extracellular membrane through association with S100A10.,subunit:The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B. Found in a number of complexes with PRX, TCTEL1 and PDZD2. Interacts with proteins such as FSTL1, PRX, TCTEL1, PDZD2, S100A10 and many others (By similarity). Interacts with NEDD4 and NEDD4L.,tissue specificity:Expressed in the dorsal root ganglia and sciatic nerve.,