caution:The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among authors.,function:Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.,PTM:Phosphorylated (Possible).,similarity:Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.,tissue specificity:Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine.,
Membrane; Multi-pass membrane protein.
Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine.
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