catalytic activity:Acyl-CoA + cholesterol = CoA + cholesterol ester.,disease:Accumulation of insoluble cholesterol esters in macrophages and smooth muscle is a characteristic feature of early lesions of atherosclerotic plaque.,function:Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.,induction:Highly activated by the presence of cholesterol.,similarity:Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.,subunit:May form homo- or heterodimers.,
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Macrophage,Placenta,
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