catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.,induction:Isoform 3 is quickly down-regulated in response to vascular injury, when ASMC cells change from a quiescent to a proliferative phenotype.,miscellaneous:Expression is under the tight control of the locus control region (LCRs).,PTM:May be autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 protein kinase domains.,similarity:Contains 9 Ig-like (immunoglobulin-like) domains.,subunit:Isoform 3 is found as a monomer or homodimer.,tissue specificity:Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly espressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of arteriosclerosis.,
[Isoform 3]: Nucleus.
Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis.
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