TPSN Polyclonal Antibody

domain:The N-terminus is required for efficient association with MHC class I molecule and for a stable interaction between MHC I and calreticulin. Binding to TAP is mediated by the C-terminus region.,function:Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).,online information:TAPBP mutation db,polymorphism:The 2 alleles of TAPBP; TAPBP*01 (Tapasin*01) (shown here) and TAPBP*02 (Tapasin*02); are in linkage disequilibria with the HLA-DRB1 locus in a Japanese population.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Interacts with TAP1 and is thus a subunit of the TAP complex. Interaction with TAP1 is TAP2 independent and is required for efficient peptide-TAP interaction. Obligatory mediator for the interaction between newly assembled MHC class I molecules, clareticulin, ERp57 and TAP. Up to 4 MHC class I/tapasin complexes bind to 1 TAP.,tissue specificity:Neutrophils, mostly in fully differentiated cells.,