catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,subunit:Interacts with FAM82A2.,tissue specificity:PTPA isoform is probably the major PTP expressed in human tissues. PTPB isoform was found in T-cells and in placenta.,
[Isoform 1]: Endoplasmic reticulum . Endoplasmic reticulum-Golgi intermediate compartment . Targeted to the endoplasmic reticulum by its C-terminal hydrophobic region. .; [Isoform 2]: Nucleus. Cytoplasm. Cell membrane. Predominantly localizes to chromatin (By similarity). Able to shuttle between the nucleus and the cytoplasm and to dephosphorylate plasma membrane receptors (PubMed:9488479). Recruited by activated ITGA1 at the plasma membrane. .
Ubiquitously expressed. Isoform 2 is probably the major isoform. Isoform 1 is expressed in T-cells and in placenta.
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