function:Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation.,induction:Highly expressed in mitotic cells from metaphase to telophase. Expression in non-mitotic cells is very low.,similarity:Contains 1 UBA domain.,similarity:Contains 1 ubiquitin-like domain.,subcellular location:Where it colocalizes with the proteasome. Associated with fibers in mitotic cells.,subunit:Binds UBE3A and BTRC. Interacts with the 19S proteasome subunit.,
Cytoplasm . Nucleus . Membrane . Cytoplasmic vesicle, autophagosome . Colocalizes with a subset of proteasomes, namely those that are cytoskeleton associated or free in the cytosol. Associated with fibers in mitotic cells. .
Amygdala,B-cell,Fetal brain,Lung,
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