function:Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.,similarity:Belongs to the Bcl-2 family.,subunit:Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1.,tissue specificity:Widely expressed in adult tissues. Preferentially expressed in the lungs, the liver and the kidneys.,
Mitochondrion . Nucleus membrane . Endoplasmic reticulum . Cytoplasm, cytoskeleton, spindle . Localizes to mitochondria-associated endoplasmic reticulum membranes (MAMs) (PubMed:27995898). Localization to MAMs is greatly reduced under apoptotic stress conditions (PubMed:27995898). .
Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney.
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