function:Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds p75NTR and antagonizes its association with TrkA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate p53 transcriptional activity and inhibit cell proliferation. Enhances p53 phosphorylation and accumulation.,similarity:Contains 1 MAGE domain.,subcellular location:Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.,subunit:Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A (By similarity). Interacts with the p75 neurotrophin receptor.,tissue specificity:Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.,
Cytoplasm . Cell membrane ; Peripheral membrane protein . Nucleus . Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. .
Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
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