catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Activated by calcium/calmodulin.,function:Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,tissue specificity:Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.,
Cell membrane ; Multi-pass membrane protein . Cytoplasm . Cell projection, cilium . Golgi apparatus . Also detected in the cytoplasm, close to lipid droplets. .
Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle (PubMed:9920776). Detected in testis (PubMed:15705663).
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