ESRP2 Polyclonal Antibody

function:mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.,induction:Down-regulated during the epithelial-to-mesenchymal transition (EMT).,similarity:Belongs to the ESRP family.,similarity:Contains 3 RRM (RNA recognition motif) domains.,tissue specificity:Epithelial cell-specific.,