catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,function:Acts as repressor of transcription (By similarity). Has histone acetyltransferase activity, with a preference for histone H4.,miscellaneous:Interaction with HDAC1 or HDAC2 prevents coenzyme A binding.,similarity:Contains 1 chromo domain.,subunit:Interacts with HDAC1 and HDAC2 via its C-terminal acetyl-CoA-binding domain.,tissue specificity:Ubiquitous. Expressed at moderate levels in all tissues examined.,
[Isoform 2]: Nucleus . Chromosome . Recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) on chromatin (PubMed:19808672). Multimerization is required for chromatin-binding (PubMed:19808672). Recruited to sites of DNA double strand breaks in a PARP1-dependent fashion (PubMed:29177481). .
Expressed in the hippocampus with reduced expression in epileptic tissue compared to normal adjacent tissue (at protein level) (PubMed:28842554). Ubiquitous (PubMed:19808672). Expressed at moderate levels in all tissues examined (PubMed:19808672). Isoform 2: Most abundantly expressed isoform (PubMed:19808672).
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