alternative products:Experimental confirmation may be lacking for some isoforms,similarity:Contains 1 J domain.,similarity:Contains 2 UIM (ubiquitin-interacting motif) repeats.,tissue specificity:Brain (neuronal layers). Weakly, in skeletal muscle and spleen.,
[Isoform 2]: Cytoplasm . Nucleus .; [Isoform 1]: Endoplasmic reticulum membrane ; Lipid-anchor ; Cytoplasmic side .
More abundantly expressed in neocortex, cerebellum, spinal cord and retina where it is expressed by neuronal cells (at protein level) (PubMed:1599432, PubMed:12754272). Detected at much lower level in non-neuronal tissues including kidney, lung, heart, skeletal muscle, spleen and testis (at protein level) (PubMed:12754272, PubMed:1599432). Isoform 1 is more abundant in neocortex and cerebellum compared to isoform 2 (at protein level) (PubMed:12754272).
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