domain:Composed of two functionally independent domains. The N-terminal domain forms an hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.,function:May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.,similarity:Belongs to the MAPRE family.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 EB1 C-terminal domain.,subcellular location:Associated with the microtubule network. Accumulates at the plus end of microtubules.,subunit:Interacts with DCTN1. Binds to the C-terminal domain of APC. Binds monomeric and polymerized tubulin.,tissue specificity:Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes.,
Cytoplasm, cytoskeleton . Associated with the microtubule network. Accumulates at the plus end of microtubules.
Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes.
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