disease:Defects in PROP1 are a cause of combined pituitary hormone deficiency (CPHD) [MIM:601538, 262600]. It is characterized by impaired production of growth hormone (GH) and one or more of the other five anterior pituitary hormones.,function:Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.,similarity:Belongs to the paired homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Expressed specifically in embryonic pituitary.,
Nucleus .
Expressed specifically in embryonic pituitary.
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