ANPRB Polyclonal Antibody

catalytic activity:GTP = 3',5'-cyclic GMP + diphosphate.,disease:Defects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type (AMDM) [MIM:602875]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDM is an autosomal recessive form characterized by axial skeletal involvement with wedging of vertebral bodies. In AMDM all skeletal elements are present but show abnormal rates of linear growth.,function:Receptor for atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). Has guanylate cyclase activity on binding of ligand. The activation order seems to be CNP > BNP > ANP.,miscellaneous:There seem to be at least three natriuretic peptide hormone receptors: two with guanylate cyclase activity (NPR1/ANP-A and NPR2/ANP-B) and one (NPR3/ANP-C) which is probably responsible for the clearance of natriuretic peptides from the circulation without a role in signal transduction.,PTM:Phosphorylation of the protein kinase-like domain is required for full activation by CNP.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 1 guanylate cyclase domain.,similarity:Contains 1 protein kinase domain.,