catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-173 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,tissue specificity:Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the testis.,
Nucleus .
Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the testis.
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