catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:Activates the JNK MAP kinase pathway through the specific activation of the upstream MKK3 and MKK6 kinases.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Found to be perinuclear and localized to vesicular compartment.,subunit:Interacts with MKK3 and MKK6 (By similarity). Self-associates.,tissue specificity:Ubiquitously expressed, with a higher level of expression in testis and brain.,
Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Cytoplasm, cytoskeleton. Nucleus. Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus.; [Isoform 2]: Cell projection, dendrite. In dendrites, colocalizes with PCDH8. .
Ubiquitously expressed, with a higher level of expression in testis and brain.
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