domain:In addition to having a high His and Pro content, this protein has many internal repeats. 12 tandem repetitions of a 5-residue sequence (GHHPH, consensus) form a histidine-rich region.,function:The physiological function is not yet known. It binds heme, dyes and divalent metal ions. It can inhibit rosette formation and is known to interact with heparin, thrombospondin, and the lysine-binding site of plasminogen. On the basis of its homology with HMW kininogen, the His-rich region of this protein may mediate the contact activation phase of intrinsic blood coagulation cascade.,similarity:Contains 2 cystatin domains.,tissue specificity:Expressed by the liver and secreted in plasma.,
Secreted .
Expressed in macrophages and in malignant cells. Expressed by the liver and secreted in plasma (at protein level).
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