function:Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.,PTM:Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.,similarity:Contains 1 DSL domain.,similarity:Contains 8 EGF-like domains.,subunit:Interacts with Notch receptors.,tissue specificity:Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.,
Apical cell membrane ; Single-pass type I membrane protein . Cell junction, adherens junction . Membrane raft . Distributed around adherens junction in the apical endfeet through interactions with MAGI1. .
Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.
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