disease:Defects in AVP are the cause of autosomal dominant neurohypophyseal diabetes insipidus (ADNDI) [MIM:125700]. ADNDI is characterized by persistent thirst, polydipsia and polyuria. The disease is transmitted in an autosomal dominant mode and appears to be largely if not completely penetrant.,disease:Defects in AVP are the cause of autosomal recessive neurohypophyseal diabetes insipidus (ARNDI) [MIM:125700]. ARNDI is characterized by persistent thirst, polydipsia and polyuria. Most mutations are hypothesized to trigger neurodegeneration via disruption of preproAVP-NPII processing.,function:Neurophysin 2 specifically binds vasopressin.,function:Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels.,online information:Vasopressin entry,similarity:Belongs to the vasopressin/oxytocin family.,
Secreted.
Lung carcinoma,