catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,function:Component of unactivated mammalian steroid receptor complexes that sediment at 8-10 S. May have a rotamase activity. May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors.,PTM:Phosphorylation by CK2 results in loss of HSP90 binding activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Wrong choice of frame.,similarity:Contains 2 PPIase FKBP-type domains.,similarity:Contains 3 TPR repeats.,subunit:Interacts with NR3C1 and dynein (By similarity). Associates with HSP90 and HSP70 in unactivated steroid hormone receptor complexes. Also interacts with peroxisomal phytanoyl-CoA alpha-hydroxylase (PHYH). Interacts with HSF1 in the HSP90 complex.,tissue specificity:Widely expressed.,
Cytoplasm, cytosol . Mitochondrion . Nucleus . Cytoplasm, cytoskeleton . Cell projection, axon . Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor (PubMed:21730050). Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (By similarity). .
Widely expressed.
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