developmental stage:Expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines.,function:Negatively regulates TGF-beta signaling.,similarity:Belongs to the BAMBI family.,tissue specificity:High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.,
Membrane ; Single-pass type I membrane protein .
High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.
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