catalytic activity:Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.,cofactor:Binds 1 zinc ion per subunit.,similarity:Belongs to the peptidase M12A family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 MAM domain.,similarity:Contains 1 MATH domain.,subunit:Homotetramer of alpha or beta subunits; heterotetramer of two alpha and two beta subunits are formed by non-covalent association of two disulfide-linked heterodimers.,
Cell membrane ; Single-pass type I membrane protein. Secreted . Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17. .
The major site of expression is the brush border membrane of small intestinal and kidney epithelial cells.
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