catalytic activity:Cleavage of the 143-Ser-|-Lys-144 bond in insulin-like growth factor binding protein (IGFBP)-5.,cofactor:Binds 1 zinc ion per subunit.,function:Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.,similarity:Belongs to the peptidase M43B family.,similarity:Contains 5 Sushi (CCP/SCR) domains.,subunit:Monomer.,tissue specificity:Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.,
Secreted .
Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.
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