disease:Defects in MXI1 are found in some patients with prostate cancer (CaP) [MIM:176807].,function:Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Interacts with SMC3 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with RNF17.,tissue specificity:High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.,
Nucleus.
High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
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