LTBP1 Polyclonal Antibody

domain:Associates covalently with small latent TGF-beta complex via domain TB 3.,function:May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).,PTM:Contains hydroxylated asparagine residues.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,PTM:The N-terminus is blocked (isoform Short).,similarity:Belongs to the LTBP family.,similarity:Contains 18 EGF-like domains.,similarity:Contains 4 TB (TGF-beta binding) domains.,subunit:The large latent complex of TGFB1 from platelets is composed of the TGFB1 molecule non-covalently associated with a disulfide-bonded complex of a dimer of the N-terminal propeptide of the TGFB1 precursor and LTBP1. LTBP1 does not bind directly to active TGFB1. Binds to FBN1 and FBN2. Interacts with ADAMTSL2.,tissue specificity:The long isoform is found in fibroblasts.,