function:May be involved in proinflammatory activation of myeloid cells via TYROBP-mediated signaling in a calcium-dependent manner.,online information:MDL-1,similarity:Contains 1 C-type lectin domain.,subunit:Interacts with TYROBP.,tissue specificity:Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U937 and MonoMac6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate into dendritic cells.,
Cell membrane ; Single-pass type II membrane protein .
Highly expressed in bone marrow with lower levels in synovium, lung and bronchus (PubMed:20212065). Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins (PubMed:10449773). Expression is down-regulated when monocytes differentiate into dendritic cells (PubMed:10449773).
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