domain:A pair of annexin repeats may form one binding site for calcium and phospholipid.,similarity:Belongs to the annexin family.,similarity:Contains 4 annexin repeats.,subcellular location:Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes.,tissue specificity:Gut specific.,
Apical cell membrane . Cell membrane ; Lipid-anchor . Cytoplasmic vesicle . Myristoylation anchors the protein to the membrane, but the protein displays also calcium-dependent, reversible binding to lipid membranes (PubMed:30610115). Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes (PubMed:1530946). .
Detected in epithelial cells in colon and jejunum (at protein level). Detected in epithelial cells in jejunum.
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