function:As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity.,similarity:Contains 1 FERM domain.,similarity:Contains 1 I/LWEQ domain.,subcellular location:Focal adhesion plaques and synapses.,subunit:Interacts directly with PIP5K1C.,
Cytoplasm . Cell junction, focal adhesion . Cell junction, synapse . Cell membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasm, cytoskeleton . Focal adhesion plaques and synapses (PubMed:12422219). .
Brain,Epithelium,Skeletal muscle,
下载说明书
