DDC Polyclonal Antibody

catalytic activity:3,4-dihydroxy-L-phenylalanine = dopamine + CO(2).,catalytic activity:5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO(2).,cofactor:Pyridoxal phosphate.,disease:Defects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.,function:Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.,online information:Aromatic L-amino-acid decarboxylase entry,pathway:Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.,similarity:Belongs to the group II decarboxylase family.,subunit:Homodimer.,