alternative products:Experimental confirmation may be lacking for some isoforms,domain:Binding to PA seems to be effected through the VWA domain.,function:Cellular role is not yet known.,similarity:Belongs to the ATR family.,similarity:Contains 1 VWFA domain.,subunit:Binds to the protective antigen (PA) of Bacillus anthracis. Binding does not occur in the presence of calcium.,tissue specificity:Highly expressed in tumor endothelial cells but not in normal endothelial cells.,
Cell membrane ; Single-pass type I membrane protein . Cell projection, lamellipodium membrane ; Single-pass type I membrane protein . Cell projection, filopodium membrane ; Single-pass type I membrane protein . At the membrane of lamellipodia and at the tip of actin-enriched filopodia (PubMed:16762926). Colocalizes with actin at the base of lamellipodia (PubMed:16762926). .
Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
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