ERR3 Polyclonal Antibody

developmental stage:Expressed at high levels in fetal brain and also in the fetal kidney, lung and liver.,function:Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements.,miscellaneous:No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.,PTM:Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.,PTM:Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the nuclear hormone receptor family. NR3 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Homodimer. Binds TLE1, PNRC1 and PNRC2. Binds GRIP1 (By similarity). Interacts with NRIP1, NCOA1 and NCOR2.,tissue specificity:Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.,