disease:Genetic variation in HAVCR2 may influence susceptibility to rheumatoid arthritis (RA) [MIM:180300]. RA is an inflammatory disease, primarily of the joints, with autoimmune features and a complex genetic component. It is characterized by inflammation of synovial tissues and the formation of rheumatoid pannus, which is capable of eroding adjacent cartilage and bone, causing subsequent joint destruction.,function:Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.,similarity:Belongs to the immunoglobulin superfamily. TIM family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,tissue specificity:T-helper type 1 lymphocyte (Th1)-specific.,
Membrane ; Single-pass type I membrane protein . Cell junction . Cell membrane . Localizes to the immunological synapse between CD8+ T-cells and target cells. .
Expressed in T-helper type 1 (Th1) lymphocytes. Expressed on regulatory T (Treg) cells after TCR stimulation. Expressed in dendritic cells and natural killer (NK) cells. Expressed in epithelial tissues. Expression is increased on CD4+ and CD8+ T-cells in chronic hepatitis C virus (HCV) infection. In progressive HIV-1 infection, expression is up-regulated on HIV-1-specific CD8 T-cells.
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