disease:Genetic variation in DPP6 may influence susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a severely disabling and lethal disorder caused by progressive degeneration of motor neurons in the brain, spinal cord and brainstem.,function:May be involved in the physiological processes of brain function. Has no dipeptidyl aminopeptidase activity. May modulate the cell surface expression and the activity of the potassium channel KCND2.,similarity:Belongs to the peptidase S9B family.,subunit:Homodimer. Binds KCND2.,tissue specificity:Expressed predominantly in brain.,
Cell membrane ; Single-pass type II membrane protein .
Expressed predominantly in brain.
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