domain:Recognizes phosphatidyl serine via its epidermal growth factor-like domains.,function:Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid. May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. Bona fide phosphatidyl serine receptor for cell corpse clearance in macrophages.,PTM:Proteolytically processed to yield a 190 kDa protein.,similarity:Contains 1 Link domain.,similarity:Contains 17 EGF-like domains.,similarity:Contains 2 laminin EGF-like domains.,similarity:Contains 7 FAS1 domains.,subunit:Interacts with GULP1.,tissue specificity:Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes.,
Cell membrane ; Single-pass type I membrane protein . Cytoplasm . Only a small amount appears to be present at the cell surface (PubMed:17145755).
Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC-cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line.
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