disease:Defects in AMH are the cause of persistent Muellerian duct syndrome type 1 (PMDS-1) [MIM:261550]. PMDS-1 is a form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.,function:This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.,miscellaneous:Although it does not compete with EGF for receptor binding sites, MIS can inhibit the autophosphorylation of the EGF receptor in vitro.,online information:Anti-Mullerian hormone entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,
Secreted .
In ovaries, AMH is detected in granulosa cells of early growing follicles.
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