domain:Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif bind the SH2 domain of PTPN6.,function:May have an regulatory role in normal and neoplastic B cell development.,PTM:Isoform 2 is N- and O-glycosylated, and phosphorylated.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,subunit:The tyrosine-phosphorylated isoform 2 interacts with PTPN6.,tissue specificity:Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B-cell lines. Preferentially expressed in memory B cells (at protein level).,
Cell membrane ; Single-pass type I membrane protein .
Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B-cell lines. Preferentially expressed in memory B-cells (at protein level).
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