function:Cell surface receptor that may play a role in the innate and adaptive immune response.,PTM:Phosphorylated on tyrosine residues.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subcellular location:Sequestered in cytoplasmic vesicles in resting platelets. Transported to the cell surface after stimulation by thrombin. Soluble fragments can be released into the serum by proteolysis.,subunit:When phosphorylated, interacts with PTPN6 (By similarity). When phosphorylated, interacts with PTPN11.,tissue specificity:Detected in platelets, monocytic leukemia and in T-cell leukemia.,
Cell membrane ; Single-pass type I membrane protein . Cytoplasm . Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151). Transported to the cell surface after stimulation by thrombin (PubMed:15100151). Soluble fragments can be released into the serum by proteolysis (PubMed:16505478).
Detected in platelets, monocytic leukemia and in T-cell leukemia.
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