disease:Antigen found 14 times more frequently in the serum of patients with systemic lupus erythematosus (SLE) than in patients with other autoimmune diseases.,function:May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.,PTM:The N-terminus is blocked.,similarity:Belongs to the ficolin lectin family.,similarity:Contains 1 collagen-like domain.,similarity:Contains 1 fibrinogen C-terminal domain.,subcellular location:Found in blood plasma, bronchus, alveolus and bile duct.,subunit:Homopolymer; disulfide-linked. May be an octadecamer consisting of an elementary trimer unit. Does not interact with fibronectin, elastin or zymosan. Interacts with MASP1 and MASP2.,tissue specificity:Liver and lung. In liver it is produced by bile duct epithelial cells and hepatocytes. In lung it is produced by both ciliated bronchial epithelial cells and type II alveolar epithelial cells.,
Secreted. Found in blood plasma, bronchus, alveolus and bile duct.
Liver and lung. In liver it is produced by bile duct epithelial cells and hepatocytes. In lung it is produced by both ciliated bronchial epithelial cells and type II alveolar epithelial cells.
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