catalytic activity:RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).,cofactor:Binds 1 copper ion per subunit.,cofactor:Binds 2 calcium ions per subunit.,cofactor:Contains 1 topaquinone per subunit.,function:Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity.,PTM:N- and O-glycosylated.,PTM:Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.,similarity:Belongs to the copper/topaquinone oxidase family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed at lower levels in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis.,
Cell membrane ; Single-pass type II membrane protein .
Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. Isoform 2 seems to be the predominant transcript in fetal kidneys, fetal cartilage and fetal tonsils. The highest relative expression of isoform 2 occurs in skeletal muscle, heart, pancreas, kidney, and lung.
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