developmental stage:Expressed at 9 weeks in developing cartilagenous bone rudiments.,function:Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development.,PTM:After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.,similarity:Belongs to the chondromodulin-1 family.,similarity:Contains 1 BRICHOS domain.,subcellular location:Accumulated in the inter-territorial matrix of cartilage.,tissue specificity:Cartilage specific. Weakly expressed in chondrosarcoma.,
[Chondromodulin-1]: Secreted, extracellular space, extracellular matrix. Accumulated in the inter-territorial matrix of cartilage.; [Chondrosurfactant protein]: Endomembrane system ; Single-pass membrane protein .
Detected in cartilage and cardiac valves (at protein level). Detected in the laminae fibrosa, spongiosa and ventricularis layers of normal cardiac valves (at protein level). Expression is decreased cardiac valves of patients with valvular heart disease (at protein level). Weakly expressed in chondrosarcoma.
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