function:May relays signals from the cell surface to the nucleus.,similarity:Belongs to the zyxin/ajuba family.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 3 LIM zinc-binding domains.,subunit:Specifically interacts with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Interacts with PTPN13.,tissue specificity:Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas.,
Cytoplasm, cytoskeleton . Cell junction, focal adhesion . Nucleus . Cytoplasm . Shuttles between nucleus and cytoplasm (PubMed:16624523). Colocalizes with actin (PubMed:10826496). .
Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors.
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