domain:The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids.,function:Contributes to the stabilization of the junctional membrane complexes, which are common to excitable cells and mediate cross-talk between cell surface and intracellular ion channels. Probably acts by anchoring the plasma membrane and endoplasmic/sarcoplasmic reticulum. Contributes to the construction of skeletal muscle triad junctions, and plays an essential role in heart development.,similarity:Belongs to the junctophilin family.,similarity:Contains 8 MORN repeats.,subcellular location:Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands.,tissue specificity:Specifically expressed in skeletal muscle and heart.,
[Junctophilin-2]: Cell membrane ; Peripheral membrane protein . Sarcoplasmic reticulum membrane ; Single-pass type IV membrane protein . Endoplasmic reticulum membrane ; Single-pass type IV membrane protein . The transmembrane domain is anchored in sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands. .; [Junctophilin-2 N-terminal fragment]: Nucleus . Accumulates in the nucleus of stressed hearts. .
Specifically expressed in skeletal muscle and heart.
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