alternative products:Additional isoforms seem to exist,function:May play a role in host defense against tumors and pathogens. Binds Z-DNA.,similarity:Contains 2 DRADA repeats.,tissue specificity:Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver.,
Cytoplasm . Nucleus . Mainly cytoplasmic (PubMed:16876127, PubMed:16990255). Accumulates in the nucleus in response to influenza A virus (IAV) infection: senses IAV defective viral genomes RNA in the nucleus (By similarity). .; [Isoform 7]: Cytoplasm . Nucleus . Compared to isoform 1, a higher proportion of this isoform is localized in the nucleus. .
Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen (PubMed:11842111). Expressed to a lesser extent in thymus, lung and liver (PubMed:11842111).
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