domain:The second and fourth zinc fingers are involved in binding to specific viral RNAs.,function:Induces an innate immunity to viral infections by preventing the accumulation of viral RNAs in the cytoplasm. Seems to recruit the RNA processing exosome to degrade the target RNAs. Inhibits alphavirus and filovirus replication.,similarity:Contains 1 PARP catalytic domain.,similarity:Contains 1 WWE domain.,similarity:Contains 4 C3H1-type zinc fingers.,subcellular location:Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner.,subunit:Interacts with EXOSC5.,
[Isoform 1]: Cytoplasm . Nucleus . Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. .; [Isoform 2]: Cytoplasm .
Brain,Endometrium,Epithelium,Fetal liver,Kidney,Ovarian car
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