function:Could be involved in a signal transduction pathway controlling epididymal function and male fertility.,PTM:Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit .,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,subunit:Forms a heterodimer, consisting of a large extracellular region linked to a seven-transmembrane moiety.,tissue specificity:Epididymis specific. Both subunits were associated with apical membranes of efferent ductule and proximal epididymal duct epithelia.,
Apical cell membrane ; Multi-pass membrane protein .
Epididymis-specific expression (at protein level). Both subunits are associated with apical membranes of efferent ductule and proximal epididymal duct epithelia. Mainly expressed in the nonciliated principal cells of the proximal excurrent ducts. Specifically over-expressed in Ewing sarcomas but also up-regulated in a number of carcinomas derived from prostate, kidney or lung.
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